Topoisomerase 2β mutation impairs early B-cell development

DNA Topoisomerase II b and Neural Development

Garnham, Malaria Parasites and Other Haemosporidia (Blackwell Scientific, Oxford, 1966)]. Sex ratios based on counts of 50 to 75 gametocytes were found to be representative. We calculated sex ratios from either 50,000 RBCs or 100 gametocytes, whichever was less. Sex ratios are given as proportion of males. 7. R. E. Sinden, G. A. Butcher, O. Billker, S. L. Fleck,. Adv. Parasitol. 38, 53 (1996). ...

Development Lymphoid Kinase Promoter in Early B Cell Early B Cell

Measurements of sin 2β in B decays

A primary objective of particle physics since the 1964 discovery of CP non-conservation in weak decays has been the understanding of the effect as a natural feature of the structure of the weak interaction. A clue was offered in 1973 by Kobayashi and Maskawa in anticipation of the discovery of a third fermion family. With three families the unitary transformation to the weak isospin basis of th...

Topoisomerase 1 inhibition reversibly impairs synaptic function.

Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that topotecan reduces the expression of multiple long genes, including many neuronal genes linked to synapses and autism. However, whether topotecan alters synaptic protein levels and synapse function is currently unknown. Here we report that in primary cortical neurons, topotecan d...

STAT3 positively regulates an early step in B-cell development.

Transcription factors are critical for instructing the development of B lymphocytes from multipotential progenitor cells in the bone marrow (BM). Here, we show that the absence of STAT3 impaired B-cell development. Mice selectively lacking STAT3 in BM progenitor cells displayed reduced numbers of mature B cells, both in the BM and in the periphery. The reduction in the B-cell compartment includ...